Research progress on virulence factors and antibiotic resistance genes of Vibrio vulnificus based on genomics

doi:10.19871/j.cnki.xfcrbzz.2023.01.016

Abstract

Abstract: Vibrio vulnificus is a fatal opportunistic pathogen with the highest mortality among foodborn diseases. It causes infection mainly through consumption of undercooked seafood and contact of broken skin with seawater. Symptoms that occur include gastroenteritis, wound infection, and deterioration of the disease leading to sepsis, which is extremely lethal. With the rapid development of genomics sequencing technology, 285 strains of Vibrio vulnificus genome sketch sequences and 24 strains of completed sequences have been published in the National Center of Biotechnology Information(NCBI) database. The advance on genomics research of Vibrio vulnificus not only facilitates the study of typing precisely, evolutionary relationships and pathogenesis, but also facilitates the prediction of virulence factors and antibiotic resistance genes, which play an important role in rapid detection, epidemiological investigation and prevention after food poisoning caused by Vibrio vulnificus. However, there are few studies on the analysis of drug resistance in Vibrio vulnificus. In this review, we provide an overview of important virulence factors, antibiotic resistance, resistance mechanisms and resistance genes from the genomics of Vibrio vunnificus.

Key words: Vibrio vulnificus, Genome, Virulence factors, Antibiotic resistance genes, Antibiotic resistance mechanism

CLC Number:

R515

Xu Shiqin, Shi Xiaolu, Lu Huiqun, Ji Liyin, Qiu Shuxiang. Research progress on virulence factors and antibiotic resistance genes of Vibrio vulnificus based on genomics[J]. Electronic Journal of Emerging Infectious Diseases, 2023, 8(1): 74-81.

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