Abstract: Objective To study the demographic factors and clinical characteristics of blood infection (BSI) in patients with acute bacterial skin and skin structure infection (ABSSSI), and to analyze which factors are the risk factors of BSI. Method Patients with ABSSSI who visited the People's Hospital of Jianyang City between January 2017 and January 2021 were selected. The case group was patients who developed bloodstream infection (BSI) within 48h after admission, and the control group was ABSSSI patients without bloodstream infection (BSI). A retrospective case-control study was performed on both groups. Independent predictors of bloodstream infection (BSI) in ABSSSI patients were sought by multifactorial logistic regression analysis. Result Three hundred ninety-two patients were included in the study,including 196 cases in the case group and 196 cases in the control group. Independent predictors of BSI in ABSSSI patients were male (OR=1.85, 95%CI=1.11~3.66), acute renal failure (OR=2.08, 95%CI=1.18~3.66), history of the previous hospitalization (OR=2.41, 95%CI=1.24~4.93), Rural residents (aOR=2.18, 95%CI=1.38~3.4), leukocytosis (OR=2.24, 95%CI=1.41~3.55), abnormal body temperature (aOR=2.86, 95%CI=1.66~4.93). Conclusion Among demographic factors, male, previous hospitalization history, rural residents and clinical characteristics of acute renal failure, leukocytosis and abnormal body temperature are highly correlated with secondary BSI in patients with ABSSSI, which are the main high-risk factors of BSI. The results of this study can provide early warning for the early treatment of ABSSSI patients with BSI and can improve the prognosis of patients.

Key words: Acute bacterial skin and skin structure infection, Bloodstream infection, Risk factors, Demographic, Clinical features