Research progress in component analysis of exhaled breath

doi:10.19871/j.cnki.xfcrbzz.2023.02.017

Abstract

Abstract: The detection of compounds in human exhaled breath provides new methods for determining human physiological state, diagnosing disease or assessing environmental exposure. Advances in metabolomics research have enabled new tools to probe the state of human respiratory metabolism. Despite some significant challenges in sampling and analysis, exhaled breath remains an ideal medium for metabolomics applications, mostly due to its noninvasiveness, convenience, and nearly limitless availability. Several breath-based assays for endogenous or exogenous gas-phase compounds have been established and used in practice and/or clinical settings. This review provides an overview of breath analysis concepts and unique test methods and their applications. We discuss their physiological production in humans and the development and implementation of related tests separately for the respiratory biomarkers targeted in each test. The article concludes with an outlook on the direction of future respiratory research.

Key words: Breath testing, Breath biomarkers, Volatile organic compounds, Clinical practice

CLC Number:

R-33

Li Chengmu, Wu Xiaoping. Research progress in component analysis of exhaled breath[J]. Electronic Journal of Emerging Infectious Diseases, 2023, 8(2): 78-81.

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