Abstract: Objective To analyze the relationship between MELD score and ICGR15 score in patients with liver cirrhosis, and to compare the predictive efficacy of complications about ICGR15, MELD and MELD-ICGR15 score in patients with liver cirrhosis within six months and forward, so as to provide clinical basis for the choice of prevention and treatment timing of complications. Method A total of 112 patients admitted to the Department of Infectious Diseases, Shenzhen People's Hospital from April 2017 to April 2018 were enrolled. The ICGR15, MELD and MELD-ICGR15 scores of each patient were calculated. Complications within a period of time (six months,one year,two years, three years respectively)were observed. The relationship between ICGR15, MELD, MELD-ICGR15 score and complications was analyzed,to evaluate the predictive value of ICGR15, MELD and MELD-ICGR15 scores for complications in patients with cirrhosis. Sensitivity, specificity,and area under the receiver operating characteristic (ROC) curve (AUC) were used. Result The complication rate of were 48.2% (54/112)、50.0%（56/112）、50.9%（57/112）、50.9%（57/112）during six month, one year, two years, three years respectively. There was no statistically significant difference in age(t=-0.929, P=0.357), sex (χ²=0.429, P=0.521), serum creatinine (Cr) (t=-1.229, P=0.224) and INR (t=-1.825, P=0.069) between the group with and without complication. There have statistically significant differences in total bilirubin (TBil) (t=-2.869, P=0.006), serum albumin (ALB) (t=4.998, P<0.001), ICGR15(t=-5.264, P<0.001), MELD score (t=-4.678, P<0.001) and MELD-ICGR15 score(t=-6.041, P<0.001) between the two groups (P<0.05). The area under the ROC curve (AUC) of the MELD-ICGR15 score was 0.866, the 95% confidence interval was 0.799 to 0.933, the cut-off value was 47.5, the corresponding sensitivity was 0.870, and the specificity was 0.759. Incorporated in the observations among the metrics, the ROC curve of the MELD-ICGR15 score was the largest area, better than the ICGR15 (AUC: 0.824), MELD Score (AUC: 0.830),the area under the ROC curve of the MELD-ICGR15 score was the largest, better than the ICGR15 (AUC: 0.824) and MELD score(AUC: 0.830). Conclusion The ICGR15, MELD score and MELD-ICGR15 score can predict the complications in patients with cirrhosis within 6 months and forward, but the MELD-ICGR15 score is the best.

Key words: Cirrhosis of the liver, Complication, Indocyanine green clearance test, Model for end stage liver disease score