A case report of acute kidney injury caused by antituberculosis fixed-dose combination formulations

doi:10.19871/j.cnki.xfcrbzz.2023.03.013

Abstract

Abstract: A middle-aged male patient was admitted to hospital with cough, edema of both lower extremities and oliguria. The patient had a history of pulmonary tuberculosis and diabetes. The onset was diagnosed with pulmonary tuberculosis and re-treatment. After taking oral fixed-dose combination formulations for anti-tuberculosis treatment. Increased urea and creatinine. The clinical diagnosis was Acute kidney injury caused by rifampicin. After drug withdrawal and hemodialysis, the patient recovered and was discharged from the hospital. This case was used to explore the possible drugs and the mechanism of acute kidney injury by the use of antituberculosis fixed-dose combination formulations, and to analyze the relevant literature, so as to provide a reference for clinical rational drug use.

Key words: Fixed-dose combination, Acute kidney injury, Rifampicin, Antituberculous drugs, Adverse drug reaction

CLC Number:

R521

Li Jian, Yang Liangzi, Liu Zhi, Wu Pengyao, Qiu Lulu, Fu Jiapeng, Ke Xue, Gao Wenying, Li Guobao. A case report of acute kidney injury caused by antituberculosis fixed-dose combination formulations[J]. Electronic Journal of Emerging Infectious Diseases, 2023, 8(3): 64-67.

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