Abstract: Since the first drug,Azidothymidine (AZT) was used in treatment of acquired immune deficiency syndrome (AIDS), many reverse transcriptases, proteases and integrases, acting on a number of different targets of HIV replication, have been included into the antiretroviral therapy treatment (ART) system. AIDS is incurable, because none of the current available drugs can effectively eliminate the viral reservoir for HIV. AIDS has emerged as a chronic illness that is manageable with ART. However, HIV-infected individuals need to receive life-long therapy for AIDS prevention. Drug-induced adverse reactions have brought great trouble to people living with HIV, including drug-induced rash, adverse reaction of digestive system, drug-induced liver injury, nephrotoxicity, bone marrow suppression, diarrhea, metabolic disorders and so on, which are the main associated factors with the interruption of ART. It seriously affects the physical, mental and quality of life of people living with HIV. In order to comprehensively understand the associated factors and clinical manifestations of adverse drug reactions in AIDS treatment, this article reviews the adverse drug reactions and their mechanisms in people living with HIV, aiming to improve the awareness and the treatment capacity of adverse drug reactions for healthcare worker.

Key words: Human immunodeficiency virus, Antiretroviral treatment, Adverse reactions, Drug-induced liver injury, Reverse transcriptase