Abstract: Cutaneous squamous cell carcinoma (cSCC) is a malignant neoplasm originating from the epidermis or accessory organ keratin-forming cells.It mainly starts with skin nodules, gradually increases in size, and in the later stage, ulcers may appear in the center, often with bleeding or covered with purulent secretions on the surface.Infection with human immunodeficiency virus impairs cell-mediated immune function, increases the risk of cSCC and makes tumors more invasive, leading to poor prognosis.This paper reports the clinical manifestations, physical characteristics and imaging of three patients with HIV infection combined with cSCC.All three patients developed from skin nodules, and the skin lesions progressed rapidly. Among them, one case had near bone destruction and was amputated after clear diagnosis, one case had lymph node metastasis and pulmonary metastasis, which was clearly diagnosed dead a few months later, one case violated the anal canal after rapid progression and was inoperable, and three patients had a poor prognosis.HIV infected patients with skin lesions and ulcers need to be alerted to the possibility of cSCC, and pathological examination should be performed as soon as possible to clarify the diagnosis and provide timely treatment.

Key words: Human immunodeficiency virus, Cutaneous squamous cell carcinoma, Diagnostic imaging, Pathology