Abstract: Q fever is a zoonosis caused by infection with Coxiella burnetii (CB) . It has a variety of clinical manifestations, including acute and chronic infections. Q fever in children is characterized by non-specific symptoms or no obvious symptoms, so it is easy to be misdiagnosed and missed. At present, laboratory examination is the main diagnostic standard, metagenomics next generation sequencing (mNGS) plays an important role in the early diagnosis of Q fever. Q fever is not uncommon in China. Most of the patients come from rural or remote areas. However, the doctors at the grass-roots level do not know enough about q fever and their diagnostic techniques are single, which results in the delay of diagnosis and treatment, increased risk of Q fever complications in children. Three cases of children with Q fever admitted to Inner Mongolia autonomous region people's hospital were analyzed retrospectively, the aim of this study is to improve the awareness of the grass-roots doctors to Q fever, to make early diagnosis and treatment, to reduce the occurrence of the corresponding complications, and to strengthen the health education of the high-risk population of the disease by grass-roots doctors, and take timely measures to prevent the occurrence of Q fever.

Key words: Children, Question fever, Metagenomics next generation sequencing, Zoonosis