Expression and significance of C-X-C motif chemokine ligand 13 in common infectious pathogens infection

doi:10.19871/j.cnki.xfcrbzz.2023.05.015

Abstract

Abstract: C-X-C motif chemokine ligand 13 (CXCI13) can promote B cell maturation and antibody response by binding to G protein-coupled chemokine receptor (CXCR5) that locating on B cells and Tfh cells.Consequently,the inhibition of virus replication, even the elimination of virus,can be realized,which conclusively facilitating to the rapid control of inflammation.However,it should be noted that excessive increase of CXCL13 may lead to impaired immune response and further deterioration of infection. In view of these important effects, the change of CXCL13 concentration is likely to become an effective index for evaluation of disease progression and antiviral efficacy, and will be helpful for future vaccine development. In summary, the paper mainly reviews the expression and significance of CXCL13 in common infectious pathogens such as human immunodeficiency virus, hepatitis B virus infection, tuberculosis and SARS-CoV-2.

Key words: C-X-C motif chemokine ligand 13, Human immunodeficiency virus, Hepatitis B virus, Mycobacterium tuberculosis

CLC Number:

R51
R446.1

Chen Zhihui, Tan Yingzheng, Long Yunzhu. Expression and significance of C-X-C motif chemokine ligand 13 in common infectious pathogens infection[J]. Electronic Journal of Emerging Infectious Diseases, 2023, 8(5): 80-84.

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