Kinetics of dengue virus IgM/IgG antibodies and factor analysis in patients with dengue

Abstract

Abstract: Objective To investigate the kinetics of dengue virus IgM/IgG antibodies and to analyze the relationship between immune status and severity of dengue. Methods Dengue virus IgM-specific and IgG-specific antibodies in 1371 patients with dengue were detected using ELISA. Based on their levels, the primary or secondary infection was differentiated. Results The IgM antibody increased gradually with progression of the disease and the positive rate increased up to 95% at d 6 after onset of the disease. The IgG antibody increased more slowly. The incidences of primary and secondary infections of dengue were 75.02% and 24.98%, respectively. The incidence of secondary infection showed no significant difference between patients with mild and severe conditions. But the incidence of secondary infection was significantly higher in the elderly patients (52.79%) than the young and middle aged adult patients (18.39%). Conclusion sMost patients with dengue in China are diagnosed with primary infection. Higher incidence of secondary infection is observed in the elderly patients.

Key words: Dengue fever, Dengue virus, Secondary infection, Antibody, Kinetics

ZHAO Ling-zhai, YU Lei, HONG Wen-xin, QIU Shuang, YANG Hui-qin, WANG Jian, ZHANG Fu-chun. Kinetics of dengue virus IgM/IgG antibodies and factor analysis in patients with dengue[J]. Electronic Journal of Emerging Infectious Diseases, 2018, 3(2): 102-105.

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