Abstract: Objective To explore the CT manifestations and characteristics of mono-resistant pulmonary tuberculosis in the primary therapy,in order to raise awareness of mono-resistant pulmonary tuberculosis among population. Methods 30 patients with mono-resistant pulmonary in the primary therapy from Baoan Chronic Diseases Prevent and Cure Hospital between July 2015 and December 2017 were treatedas the mono-resistant group, and 30 patients with sensitive to anti tuberculosis drugs in the primary therapy during the same period were selected as the control group. The difference in age,gender,the distribution of lesions and CT manifestations in two groups were analyzed by statistical software. Results Chi square test showed that there was no significant difference in gender and disease distribution between the single drug resistance group and the control group (P>0.05),The age of single drug resistance group was smaller than that of the control group (P<0.05). The incidence of single drug resistance in large lobar or segment type, atelectasis, non-wall cavity and bronchial thickening was significantly higher than that of the control group (P<0.05), and the incidence of lymph node calcification in the mediastinal mediastinum was significantly lower than that of the control group (P<0.05). The incidence of calcification in mediastinal lymph nodes was significantly lower than that in the control group (P<0.05). Multifactor logistic regression analysis showed that large lobar or segmental consolidation, non-wall cavity, bronchial thickening and stenosis,non-calcification of hilum and mediastinal lymph nodes were the main risk factors for mono-resistant pulmonary tuberculosis in the primary therapy. Conclusion TheCT manifestations of mono-resistant pulmonary tuberculosis in the primary therapy are mainly active and extensive. When there are large lobar or segmental consolidation, non-wall cavity, bronchial thickening stenosis and non-calcification of hilum and mediastinal lymph nodes, it will be helpful for the diagnosis of mono-resistant pulmonary tuberculosis in the primary therapy.

Key words: Tuberculosis, pulmonary, Drug resistance, CT