Abstract: Objective To explore the preventive effect of different application methods of antibiotics on infection after interventional therapy in patients with myocardial infarction after interventional therapy. Methods 200 patients with acute myocardial infarction who underwent interventional therapy in our hospital were divided into group A, group B, group C and group D according to the application method of antibiotics. Group A (50 cases) used antibiotics preoperatively and postoperatively, group B (50 cases) used antibiotics before operation, group C (50 cases) did not use antibiotics before operation and antibiotics were used after operation, and group D (50 cases) did not use antibiotics before and after interventional therapy. The incidence of infection after interventional therapy was compared among the four groups, and hospital stay were recorded. Results The incidence of infection was 4%, 6%, 6% and 18% in group A, group B, group C and group D after interventional therapy. There was no significant difference in the incidence of infection between group A, group B, and group C. The incidence of infection in group A, group B and group C was significantly lower than that in group D (P<0.05). The average hospitalization time of group A, group B, group C and group D was (8.7+1.2) d, (8.5+1.4) d, (8.4+1.1) D and (14.3+1.2) D. The average hospital length of stay of group A, group B and group C was significantly shorter than that of group D. The difference between groups was statistically significant (P<0.05). Conclusion The use of antibiotics before and after interventional surgery can effectively prevent post-operative infection of acute myocardial infarction, and should be reasonably applied in clinic.

Key words: Myocardial infarction, Interventional therapy, Postoperative infection, Preventive effect