A descriptive study of the global first case of pneumonia caused by human-infected avian influenza virus H9N2

Abstract

Abstract: Objective To discuss the imaging features of pneumonia caused by human-infected avian influenza virus H9N2. Methods A descriptive study was carried out on a case of pneumonia caused by human-infected avian influenza virus H9N2 in Meizhou,Guangdong Province,on June 18,2016. Results The patient was a child with cough, and white phlegm was detected followed by yellow sticky sputum,accompanying with fever. Imaging features included exudative patchy ground glass opacity,and pulmonary fibrosis was visible during the recovery period.The patient was discharged from hospital after antiviral and symptomatic treatments. Conclusion For pneumonia caused by human-infected avian influenza virus H9N2,except for the symptoms of influenza,exudative focus was present in bilateral lung CT images.Clinicians should consider the possibility of viral infection in children who had contact history with poultry and got fever and pulmonary infection.Early diagnosis and antiviral therapy are important to improve the prognosis.

Key words: Avian influenza virus, H9N2, Pneumonia, Imaging manifestations

HOU Wen-zhong, ZHANG Qian-qian, LUO Cai-mei, LU Pu-xuan. A descriptive study of the global first case of pneumonia caused by human-infected avian influenza virus H9N2[J]. Electronic Journal of Emerging Infectious Diseases, 2016, 1(1): 18-22.

References

[1] 李宏军,陆普选,施裕新.流行性感冒影像[M].北京:科学出版社,2016:93.
[2] 陆普选,周伯平.新发传染病临床影像诊断[M].北京:人民卫生出版社,2013:87-87.
[3] Pu-xuanLu,Bo-pingZhou.Diagnostic Imaging of Emerging Infectious Diseases[M].Springer Netherlands,2016:29-56.
[4] Fouchier R A,Munster V,WallenstenA,et al.Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls[J].Journal of Virology, 2005,79(5):2814-2822.
[5] Guo Y1,Li J,Cheng X.Discovery of men infected by avian influenza A (H9N2) virus[J].Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi,1999,13(2):105-108.
[6] K.M.Butt,Gavin J.D.Smith,HonglinChen,et,al.Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003[J].J ClinMicrobiol,2005,43(11):5760-5767.
[7] Yiwei Huang,XiaodanLi,Hong Zhang,et al.Human infection with an avian influenza A (H9N2) virus in the middle region of China[J].Journal of Medical Virology,2015, 87(10):1641-1648.
[8] Homme P J,Easterday B C.Characteristics of influenza A-turkeyWisconsin-1966 virus[J].Avian Disease,1970,14(1):66-74.
[9] Guan Y,Shortridge KF,Krauss S,et al.H9N2 influenza viruses possessing H5N1-like internal genomes continue to circulate in poultry in southeastern China[J].J Virol, 2000,74(20):9372-9380.
[10] Kung NY, Guan Y,Perkins NR,et al.The impact of a monthly rest day on avian influenza virus isolation rates in retail live poultry markets in Hong Kong[J].Avian Dis,2003,47(3):1037-1041.
[11] 张传美,H9N2亚型禽流感病毒感染水貂的研究[D].北京:中国农业大学,2016.
[12] Alexander DJ.An overview of the epidemiology of avian influenza[J].Vaccine,2007,25(30):5637-5644.
[13] Fusaro A,Monne I,Salviato A,et al.Phylogeography and evolutionary history of reassortant H9N2 viruses with potentialhuman health implications[J].J Virol,2011,85(16):8413-8421.
[14] Peiris M,Yuen KY,Leung CW,et al.Human infection with influenza H9N2[J].Lancet,1999,354(9182):916-917.
[15] Saito T,Lim W,Suzuki T,et al.Characterization of a human H9N2 influenza virus isolated in Hong Kong[J]. Vaccine,2001,20(1-2):125-133.
[16] Guo YJ,Wen LY,Wang M,et al.Characterization of internal genes of two strains of influenza A(H9N2) virus isolated from men[J].Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi,2003,17(3):225-228.
[17] Wang C,Lee HH,Yang ZF,et al.PB2-Q591K Mutation Determines the Pathogenicity of Avian H9N2 Influenza Viruses for Mammalian Species[J].PLoS One,2016,11(9):e0162163.
[18] 陆普选,曾政,郑斐群,等.人感染H7N9禽流感病毒性重症肺炎的影像学表现及动态变化特点[J].放射学实践,2014,29(7):740-744.
[19] 李晶晶,曾政,陆普选,等.人感染H7N9禽流感病毒性肺炎影像学随访研究[J].放射学实践,2016,31(3):228-231.
[20] 曾政,陆普选,周伯平,等.人感染H7N9禽流感病毒致重症肺炎的影像学表现[J].结核病与肺部健康杂志,2014,3(1):25-28.
[21] 李莉,李宏军,赵晶,等.13例人感染H7N9禽流感的胸部影像特点[J].放射学实践,2014,29(7):748-750.
[22] 陆普选,朱文科,叶如馨,等.成人H5N1亚型禽流感病毒性重症肺炎的CT表现与动态变化[J].中国CT和MRI杂志,2007,5(1):31-34.
[23] 陆普选,周伯平,朱文科,等.高致病性H5N1亚型人禽流感病毒性肺炎的影像学表现特点[J].中国医学影像技术,2007,23(4):532-535.