Abstract: Objective This study aimed to investigate the effects of reducing the rate of vertical transmission via risk assessment and intervention treatment based on the evaluation of HBV infection management during pregnancy. Methods Analysis was conducted to review 560 HBV-infected pregnant women who attended to our hospital during the period between June 2014 and June 2016.The liver function tests,way of delivery,and neonate vaccination were analyzed to explore the influence of the maternal viral load on the neonates.Detecting the viral load,liver function and HBV markers from the start of birth to delivery to analyze the risk of premature delivery,cesarean section rate and the transmission rate of mother-to-child on which hepatitis B virus in pregnant women with different viral load. Results Statistical analysis showed that the conversion-rate difference between the two groups(high/low viral load group) was not significant,but the high viral load group demonstrated longer liver function recovery, higher rate of employing cesarean section, and higher rate of preterm labor.The HBsAg, HBeAg,and HBV-DNA positive rate of neonates from the high viral load group were statistically significant higher than those of the low viral load group. Conclusions Normalized risk assessment and standardized intervention treatment to HBV-infected pregnant women are necessary for the reduction of vertical transmission rate.

Key words: Virus B hepatitis, Pregnant woman, Viral load, Mother-to-child transmission